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Little Seneca Creek is located in Montgomery County, Maryland roughly 18 miles to the northwest of Washington, D.C. The creek drains portions of Clarksburg, Germantown, and Boyds. It rises south of Damascus and flows southward about 5 miles to Little Seneca Lake, a reservoir created by construction of a dam on the creek. The reservoir empties to the lower portion of the creek, which flows south about 5 miles to Seneca Creek, which drains to the Potomac River and the Chesapeake Bay.